Benign pancreatic hyperenzymemia or Gullo's syndrome.

Healthy Chinese with benign pancreatic hyperenzymemia.

Benign pancreatic hyperenzymemia, or Gullo's syndrome, is an uncommon syndrome characterized by a long-term increase of serum pancreatic enzyme in the absence of pancreatic diseases. It is primarily discovered incidentally and occurs in either sporadic or familial form. Herein, we report the first case of benign pancreatic hyperenzymemia in Taiwan. A 57-year-old Chinese male was incidentally no...

Benign pancreatic hyperenzymemia (Gullo syndrome), histamine intolerance, and carbohydrate malabsorption.

Benign pancreatic hyperenzymemia (Gullo syndrome) is characterized by a more than threefold increase of the pancreatic enzymes lipase and amylase in the absence of a pancreatic disease over a period of more than 1 year, with elevations and significant undulations of pancreatic enzyme serum concentrations occurring on a day-to-day basis for 5 consecutive days. Nonspecific abdominal complaints ma...

Asymptomatic and Persistent Elevation of Pancreatic Enzymes in an Ulcerative Colitis Patient

Azathioprine has been extensively used in the management of inflammatory bowel diseases. It might cause pancreatic damage in the form of either asymptomatic elevation in serum amylase/lipase or overt acute pancreatitis. Here we report the case of a 61-year-old patient with ulcerative colitis who had been treated with azathioprine for three years, achieving clinical remission. During treatment h...

Chronic asymptomatic pancreatic hyperenzymemia: is it a benign anomaly or a disease?

Familial Pancreatic Hyperenzymemia

Asymptomatic chronic pancreatic hyperenzymemia is characterized by an increase in serum amylase and/or lipase concentrations and was first described by Pieper-Bigelow et al. [1], in 1990 who called the condition ‘‘asymptomatic chronic hyperamylasemia’’; in 1991, Ventrucci et al. [2] found that, in some patients, pancreatic hyperamylasemia may also be associated with hyperlipasemia and, finally,...